The Sensex was down 173.66 points at 30397.31, while the Nifty was down 50.10 points at 9388.15. The market breadth was negative as 376 shares advanced against a decline of 2,090 shares, while 111 shares were unchanged.
Sun Pharma, Cipla and Aurobindo Pharma lost the most, while Maruti Suzuki, Eicher Motors, and Tata Motors gained the most.
European bourses are expected to open mixed Tuesday as investors wake up to news of another terrorist incident in the U.K. and digest further political and economic turmoil in the euro zone.
The FTSE 100 is seen up by 7 points at 7,502, the DAX is expected to open lower by 1 point at 12,620 and the CAC 40 is set to start down by 2 points at 5,323.
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